Project TitleSilver Sulfadiazine - Immobilized Fillers: Preparation and Uses
Track Code2015-020
Short Description

A novel method to achieve a potent, long-term, and non-leeching antimicrobial fillers for dental composites and adhesives utilizing silver sulfadiazine-inorganic filler conjugates.

Tagssilver sulfadiazine, antimicrobial, cellulose, dental, Adhesive, restorative, filler conjugate, non-leeching, silver nitrate, potent
Posted DateApr 15, 2016 4:21 PM


Rajnish Kaushik


Numerous dental restoratives and adhesives today are composed of polymer resin or filler-based composite materials. However, bacterial adhesion and the formation of biofilms has limited the lifetime of these restoratives and adhesives. Various methods have been studied to formulate improved materials for these applications, including the addition of monomeric organic antimicrobial agents, inorganic nanoparticles, or quaternary ammonium-containing monomers, but none have shown considerable advancement.


UMass Lowell researchers have developed a method to achieve a potent, long-term, and non-leeching antimicrobial fillers for dental composites and adhesives utilizing silver sulfadiazine- inorganic filler conjugates. The sulfadiazine is first covalently attached to onto conventional inorganic fillers, such as glass powders and cotton cellulose, to produce sulfadiazine-filler conjugates. The sulfadiazine-filler conjugates are then reacted with silver sources, such as a silver nitrate aqueous solution, to form silver sulfadiazine-inorganic filler conjugates. The final filler conjugates are added to dental composite or adhesive formulations to achieve long-lasting antimicrobial effects in an easy to us manner.


Double Agar Layer (DAL) Method


AATCC Test Method 124-2001

Trypan Blue Dye Exclusion Method

Competitive Advantages

  • The covalently bonded antimicrobial agents will not leech away.
  • Silver component provides potent antimicrobial effects and is safe to use in dental applications.
  • Silver-sulfadiazine displays no discoloration over time.
  • Medical practitioners are able to use the same instruments and procedures as before, making this new filler composite easy to use.


  • Dental restoratives
  • Dental adhesives

Market Potential

In congruence with the growing global medical and dental industry, a report from Markets and Markets projects the general global medical adhesive market to reach $10,015.67 million by 2019, growing at a CAGR of 9.65% between 2014 and 2019. Additionally, the U.S. Market for Dental Materials report projects the dental materials market to reach $1.5 billion by 2020.

Intellectual Property

PCT 2016/032938 filed 18 May 2016.

References & Publications

Cao, Zhengbing, et al. "Silver sulfadiazine–immobilized celluloses as biocompatible polymeric biocides." Journal of Bioactive and Compatible Polymers 28.4 (2013): 398-410.


Rajnish Kaushik

Office of Technology Commercialization (OTC)

University of Massachusetts Lowell

600 Suffolk Street, 2nd Floor

Lowell, MA 01854